Effect of secretome of adipose stem cell (ASC) in photoaging skin

Introduction: UV light is the principal cause of photoaging, a kind aging. The problem arises because it less enjoyable. Utilizing secretome adipose stem cells (ASC), which rich in growth factors, could be novel anti-photoaging therapy. ASCs has been extensively examined for their role wound healing, but function photoaging just lately investigated. This study looked at changes epidermal and dermal thickness, expression MMP-1 TIMP-1, as well collagen density to assess influence ASC treatment. Methods: 28 male Wistar rats, 10-12 weeks old, were randomly assigned one week acclimation each four groups: UV-irradiated group with topical (Group P1); vehicle only P2); ASC, non-UV-irradiated P3); no treatment P4) P0). Prior treating exposure was administered six weeks. Then, period weeks, Results: thickness significantly improved after compared irradiated (p<0.05). TIMP-1 increased Conclusion: Secretome may solution skin.